X Curso para Postgraduados: “Fundamentos Moleculares de la Medicina

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Dr. Enrique Blázquez from the Departament of Biochemistry and Molecular Biology, Faculty of Medicine (Universidad Complutense de Madrid) organises this course with the Support of the Fundación Lilly.

Information and registration: La información sobre las inscripciones (gratuitas), podrá encontrarla en el programa adjunto y las solicitudes deben dirigirse por correo electrónico a la atención del Prof. Enrique Blázquez, antes del 18 de mayo de 2013

Room: Sede de la Real Academia Nacional de Medicina

C/ Arrieta, 12; 28013 Madrid –  Ópera

Time: 10.00 hours

Speaker: Various

Organises:  Fundación Lilly

Contact: Dr. Enrique Blázquez eblazquez@med.ucm.es

more info >>>>

The Group of Immunology of the University of Vigo, new article in Plos One

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The Group of Immunology of the University of Vigo has published the article “A Polymer/Oil Based Nanovaccine as a Single-Dose Immunization Approach” in Plos One.

Abstract

The recognized necessity for new antigen delivery carriers with the capacity to boost, modulate and prolong neutralizing immune responses prompted our approach, in which we describe a multifunctional nanocarrier consisting of an oily nanocontainer protected by a polymeric shell made of chitosan (CS), named CS nanocapsules (CSNC). The CS shell can associate the antigen on its surface, whereas the oily core might provide additional immunostimulating properties. In this first characterization of the system, we intended to study the influence of different antigen organizations on the nanocarrier’s surface (using the recombinant hepatitis B surface antigen –rHBsAg– as a model antigen) on their long-term immunopotentiating effect, without any additional immunostimulant. Thus, two prototypes of antigen-loaded CSNC (CSNC+ and CSNC−), exhibiting similar particle size (200 nm) and high antigen association efficiency (>80%), were developed with different surface composition (polymer/antigen ratios) and surface charge (positive/negative, respectively). The biological evaluation of these nanovaccines evidenced the superiority of the CSNC+ as compared to CSNC- and alum-rHBsAg in terms of neutralizing antibody responses, following intramuscular vaccination. Moreover, a single dose of CSNC+ led to similar IgG levels to the positive control. The IgG1/IgG2a ratio suggested a mixed Th1/Th2 response elicited by CSNC+, in contrast to the typical Th2-biased response of alum. Finally, CSNC+ could be freeze-dried without altering its physicochemical properties and adjuvant effect in vivo. In conclusion, the evaluation of CSNC+ confirms its interesting features for enhancing, prolonging and modulating the type of immune response against subunit antigens, such as rHBsAg.

Citation: Vicente S, Diaz-Freitas B, Peleteiro M, Sanchez A, Pascual DW, et al. (2013) A Polymer/Oil Based Nanovaccine as a Single-Dose Immunization Approach. PLoS ONE 8(4): e62500. doi:10.1371/journal.pone.0062500

Editor: Prosper N. Boyaka, The Ohio State University, United States of America

Received: December 11, 2012; Accepted: March 21, 2013; Published: April 22, 2013

Copyright: © 2013 Vicente et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: This work was supported by a grant from the Bill and Melinda Gates Foundation (www.gatesfoundation.org), Consolider Ingenio 2010 CSD2006-00012 (Ministry of Science and Innovation, Spain) and Competitive Reference Groups SUDOE-FEDER (SOE1/P1/E014). SV and MP acknowledge a fellowship from the Spanish Ministry of Education (FPU predoctoral grants). DWP was in part supported by Montana Agricultural Experiment Station and US Department of Agriculture Formula Funds. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Link: more info

Contact:

Resource: Group of Immunology of the University of Vigo.

Second Conference on Clinical Research with Private Centres

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The Spanish Technology Platform for Innovative Medicines and FARMAINDUSTRIA are co-organizing, together with the Institute for Development and Integration of Health (IDIS), the Second Conference on Clinical Research with Private Centres, to be held on April 25 in the University Hospital Auditorium Quirón in Barcelona.

Registration must be made on-line at www.medicamentos-innovadores.org Attendance is free, but limited to the capacity of the room.

Contact:

  • Amelia Martín Uranga
  • Farmaindustria
  • C/María de Molina, 54, 7ª – 28006 Madrid

Resource: Plataforma Tecnológica Española Medicamentos Innovadores, and FARMAINDUSTRIA.

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The Editorial Médica Panamericana looking into receiving original articles in biomedicine

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They are open to count with outside experts for this new Enterprise.

The idea is start including relevant information to be disseminated periodically from the application that they have created and their social networks and webpage. This will be an excellent window for the participating authors and for the dissemination and sale of the book.

For those interested, they are willing to receive the current affairs in which you are interested. This could be about your work, interesting clinical cases, or any other subject relevant for the community.

The accepted format is a Word document of about 600-700 words (in any case, more than 500 and less than 1,000). Images and tables are accepted. The articles must be original and have never been published before.

Contact details:

  • Alejandro Nieto
  • Departamento de Marketing y Comunicación
  • anieto@medicapanamericana.es
  • Editorial Médica Panamericana
  • Quintanapalla, 8, 4º B – 28050 Madrid
  • Teléfono: +34 91 131 78 00 ( ext. 2151 )

More info: http://www.medicapanamericana.com

Presentation of Professor África González in the Club Faro.

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On the 22nd of November, Professor África González Fernández was invited to participate in the Club Faro sessions with the talk “Nanomedicine: ¿a new science?”.

The presentation ended with a dynamic open conversation with several of the attendants, resulting in an interesting subject also for the general public.

More info: http://www.farodevigo.es/gran-vigo/2012/11/28/animalario-universidad-recibe-primeros-equipos-tecnicos-tecnologicos/718282.html

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