Wednesday 30th of May of 2018 at 10:30 a.m.; Conference room, Torre CACTI (0 floor).
Tittle: How yeast and cancer cells meet as a tool to identify new molecular targets for colorectal cancer therapy
The speaker will be Dra. Ana Preto, from CBMA- Molecular and Environmental Biology Centre, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
This conference is organized by the group of Immunology.
The talk will be in English. Abstract:
Colorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the 2nd cause of cancer related deaths. The type of diet is an important risk factor for CRC. Dietary fiber and the gut microbial-derived short chain fatty acids (SCFA), namely acetate, propionate and butyrate, exert multiple beneficial effects on the colon energy metabolism and have a role in the regulation of CRC cells survival. Several genes have been implicated in the multistep genetic model of colorectal carcinogenesis, being KRAS oncogene mutations (KRASm) frequent events in this process. During the last years, we have been using yeast and human colon cells as complementary models in order to identify new molecular targets and therapeutic approaches for CRC. This talk will focus on our recent published results namely in the mechanism by which acetate regulates CRC cells-induced apoptosis and in the role of KRASm signaling on autophagy regulation in CRC.
In brief, our findings indicated that lysosomal cathepsin D is implicated in acetate-induced apoptosis and its inhibition sensitizes CRC cells, what could be used as a novel therapeutic strategy. Moreover, our results also show a role of KRASm in induction of autophagy, suggesting the use of autophagy inhibitors as an alternative therapeutic approach in CRCs harboring mutated KRAS.