“The role of proteolytic systems and metabolism in acute myeloid leukemia“
Dr. Paula Ludovico
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga.
Xoves, 11 Abril 2019, 12 H.
Sala de Conferencias CACTI (Torre CACTI-Planta 0).
Acute myeloid leukemia (AML) comprises a heterogeneous group of hematologic neoplasms characterized by diverse combinations of genetic, phenotypic and clinical features representing a major challenge for the development of targeted therapies.
Metabolic reprogramming, mainly driven by deregulation of the nutrient-sensing pathways as AMPK, mTORC1 and PI3K/AKT, has been associated with AML cells’ survival and proliferation. Nevertheless, the role of these metabolic adaptations on the AML pathogenesis is still controversial.
The metabolic status and the respective metabolic networks operating in different AML cells and their impact on autophagy and survival will be discussed. Inhibition of the nutrient-sensing pathways is disclosed as a promising therapeutical target in some scenarios.
An exclusive metabolic profile for each AML cells and its impact on determination of the anti-leukemia efficacy and on personalized combinatory therapy with conventional and targeted agents will be highlighted.