FB3 B Neuroscience

Jose Antonio LamasDr. José Antonio Lamas Castro

(PhD, Neurophysiologist)

tl_files/cinbio/imagenes/telefono.png +34 986 812563 – +34 986 814067
tl_files/cinbio/imagenes/arroba.png antoniolamas@uvigo.es
tl_files/cinbio/imagenes/masinfo.gif Neuroscience Web
Currently they use mainly electrophysiology in neuronal cultures, but also RT-PCR, qRT-PCR and immunocytochemical techniques to understand how ion channels adjust neuronal behavior. Ion channel dysfunction is the origin of a group of clinically relevant diseases called channelopathies, so that their study may be important to understand some types of epilepsy, cancer, Alzheimer, cardiac arrhythmia… In particular they are interested in:
  • The expression and distribution of the “leakage” two-pore-domain potassium channels (K2P) in the Autonomic Nervous System.
  • The properties of K2P potassium channels and currents in sympathetic neurons from the superior cervical ganglion (SCG) and nodose ganglion (NG).
  • The modulation of K2P potassium channels by muscarinic agonists, nootropic agents and other second messenger pathways.
  • The role of K2P channels in the resting membrane potential and excitability of neurons.
  • The action of clinically appealing drugs such as linopirdine, XE991, riluzole, fluoxetine or valproate on K2P channels but also on other neuronal excitability related channels and currents (HCN, KCNQ, persistent sodium currents…)

The Group of Neurological Science collaborates with other Spanish groups, mainly:

  • Group or Prof. Andrés Morales from the University of Alicante on the blockade of nicotinic channels by local anesthetics.
  • Group of Profs. Teresa Giráldez and Diego Álvarez de la Rosa from the university of La Laguna on the interaction of SGK1 with KCNQ potassium channels.

This group belongs to the Spanish Ion Channel Network (RECI: Red Española de Canales Iónicos), and are also part of the Spanish Ion Channel Initiative (SICI), a consortium funded by the Spanish Research Council (CONSOLIDER-INGENIO).