Dr. Shizuo Akira & Dr. Gabriel Núñez - CINBIO Seminar Programme 18 September 2023 Sala de seminarios da Torre CACTI

Programa Seminar Programme


Na Sala de Seminarios da Torre CACTI

  • 10.00-10.45 Dr. Shizuo Akira - Osaka University

 Conference Title: “Regnase-1, an endoribonuclease involved in inflammation, immunity and metabolism”

 Abstract :

Regnase-1 is an endoribonuclease involved in destabilization of a variety of mRNAs including IL-6 and Regnase-1 itself mRNAs. Regnase-1 knockout mice show generalized inflammation. Rengase-1 is phosphorylated by a variety of stimuli. We generated a variety of tissue-specific KO mice and phosphorylation-resistant knock-in mice. I will talk about the role of Regnase-1 in a variety of cells and tissues.


  • 11.00-11.45 Dr. Gabriel Núñez - University of Michigan Medical School

 Conference Title: “Host-Microbiota Interactions in Health and Disease”


The intestinal tract of mammals is colonized by a large number of microorganisms that are referred to collectively as the gut microbiota.  The seminar will focus on research performed in our laboratory to understand the mechanisms by which the microbiota protect the host from pathogen colonization and promote inflammatory disease in susceptible individuals.

  • 12.00 Vino español


Dr. SHIZUO AKIRA. Osaka University, Japan.

 He graduated Osaka University Medical School in 1977 and received his Ph.D. from the same institution in 1984. He spent the period from 1985 to 1987 as a Research Fellow in the Department of Microbiology and Immunology, California University. He returned to the Institute for Molecular and Cellular Biology in Osaka University, where he remained until 1996. After working in Hyogo College of Medicine for 3 years, he served as a Professor at RIMD from 1999 to 2018. Having concurrently served as the Director for WPI Immunology Frontier Research Center (IFReC), Osaka University from 2007 to 2019, he was appointed as SA Professor at IFReC and concurrently RIMD in 2018. (H index: 298. Over 437.000 citations).


Dr. GABRIEL NUÑEZ . Paul de Kruif Endowed Professor of Pathology. University of Michigan, Medical School, USA.

 Gabriel Nuñez earned his M.D. degree from the University of Seville, Spain and received postdoctoral training at the University of Texas Southwestern Medical Center, Dallas and Washington University in Saint Louis. In 1991, he joined the Department of Pathology at the University of Michigan in Ann Arbor where he holds the Paul de Kruif Endowed Professorship in Academic Pathology. His laboratory identified NOD1 and NOD2, the first members of the Nod-like receptor (NLR) family, a class of pattern-recognition receptors that mediate cytosolic sensing of microbial organisms. Nuñez and colleagues showed that genetic variation in a NLR family member, NOD2, is strongly associated with susceptibility to Crohn's disease. He is an elected member of the National Academy of Medicine of the United States. Dr. Nuñez is the author of more than 400 scientific publications (h-index: 164; 138,500 citations).

Formulario de asistencia

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