Seminario 15mar18: Cancer genomics 09 March 2018

O xoves, 15mar2018 at 10 h., na “Sala de Audiovisuales” de CINBIO, módulo 6 (¡ollo, nova sala!).

Ponente: Dra. Sonia Prado López, do laboratorio de Single Cell laboratory (Grupo de Xenómica Evolutiva e Biomédica).

Tito da charla: Cancer genomics (a conferencia estará en español.)

Presentaranse as diferentes ferramentas de investigación, dentro do grupo de investigación Evolutionary and Biomedical Genomics, dedicado ao estudo da heteroxeneidade e evolución do tumor en diferentes tipos de cancro.

Abstract:

Cancer is a genetic disease arising from the unregulated clonal (i.e., genetically identical) expansion of cells that have mutated by chance at some key genes known as cancer genes. Cancer cells multiply much faster than tumor growth (2), implying that selection for space and resources of cancer cells is strong and that many cells die without dividing (3). Indeed, cancer has been long recognized as an evolutionary process mainly driven –at least at the beginning– by continuous Darwinian natural selection of the fittest clones (4,5,6). Because of this, it is not surprising that most human cancers show high levels of intratumor heterogeneity at the phenotype and genotype levels (7,8,9,10) with important implications not only for diagnosis and treatment but also for progression (11,12).

1. Clarke, M. F. & Fuller, M. Co 124, 1111–1115 (2006).
2. Klein, C. A. Nat. Rev. Cancer 9 (2009)
3. Greaves, M. & Maley, C. Nature  481, 306–313 (2012).
4. Wu, C.-I. et al  Annu. Rev. Gent (2016).
5. Nowell, P. C. Science 194, 23–28 (1976).
6. Cairns, J. Nature 255,197-200(1975)
7. Lu,Y.W.etal .PlosOne 11 (2016)
8. Michor, F & Polyak, K. Cancer Prev.Es.Phila.Pa3 (2010)
9. Swanton, C. Cancer Res. 72, 4875-4882 (2012)
10. Williams, M.J. et al Mol. Cell. Oncol.
11. Merlo, L.M.F et al Cancer Prev.Res Phila.Pa 3, (2020)
12. Martínez-Cardús, A. et al Gastroenterology (2016)