Eventos
O xoves 6 de febreiro de 2025, a Dr. Guadalupe Sabio (Centro Nacional de Investigaciones
Oncológicas, CNIO) ofrecerá o seminario “Metabolic Drivers of Cancer and Obesity-related Diseases" dentro do ciclo CINBIO Seminar Programme.
Será ás 11:00 horas na Sala de seminarios de Torre CACTI.
ABSTRACT:
Our previous research demonstrated that pathological adipose tissue (AT) induces alterations in adipokine secretion, contributing to the progression of metabolic diseases and cancer development, including NASH, HCC, and potentially cardiovascular conditions. This underscores the role of AT as a pivotal endocrine organ with a significant impact on whole-body metabolism, highlighting that its dysfunction not only affects the liver but also other organs. Notably, we have identified adipokines that correlate with an increased risk of liver cancer and may also play a role in cardiovascular diseases.
In this context, our current goal is to identify a combination of adipokines that could form a composite biomarker to predict cancer risk in individuals with obesity. Additionally, inducing genetic alterations in mouse adipose tissue to mimic obesity characteristics leads to spontaneous liver cancer development and potential cardiovascular alterations, emphasizing the critical role of adipose tissue in initiating and progressing cancer and other diseases. Using this mouse model, we aim to uncover how adipose tissue dysfunction contributes to cancer development, identify predictive adipokines, and establish novel biomarkers. These findings hold promise for advancing our understanding and identifying therapeutic targets in the fight against cancer and related conditions.
BIO:
Graduated in Veterinary Sciences from the University of Extremadura, where she completed her thesis with the award to the best University Thesis (2001). Dr. Sabio obtained her doctorate from the British Medical Research Council in Dundee and the University of Extremadura under the supervision of Dr. Ana Cuenda, in Philip Cohen's department where she discovered various substrates of p38 and p38. This work is documented in Biochem J (2004) and EMBO J (2005). Award to the best Doctoral Thesis at the U.of Extremadura (2005).
After obtaining her doctorate, she moved to UMASS (Worcester, MA, USA) to study the in vivo function of MAPK together with Dr. Roger Davis. There she made important contributions to the understanding of the role of JNK1 in different tissues and its implication in diabetes. This progress was reflected in several publications as first author. In Science (2008), she described the interaction of adipose JNK1 with the liver. The rest of the results during her stay at UMass were published in Cell Metab (2009), Mol Cell Biol (2010), Genes & Development (2010) and Trends Biochem Sci (2010). Other collaborations appear in Science (2008), Int J Biol Sci (2009), J Immunol (2011), Blood (2011), Cell (2009) or Cell Metabolism (2014).
Afterwards she established as an independent PI at CNIC, funded by an ERC Starting Grant. She works on the role of stress kinases in the development of metabolic diseases and cancer, trying to understand the role of this signaling pathway. Her studies analyzing the function of these kinases in liver metabolism and the development of cancer stand out. Journal of Clinical Investigation, EMBO J, Nature, PNAS, Elife. She has also studied the contribution of these kinases in the metabolism of adipose tissue and its effect as an endocrine organ Nature Communications, Plos Biol, Journal Experimental Medicine. She has recently focused on studying the role of SAPKs in the maintenance of cardiac metabolism and functionality: Nature Communication, Plos Biol. Currently her research focuses on understanding the interaction between different tissues during homeostasis and disease focusing on the key points, the response to stress, the control of the circadian rhythm and the metabolic regulation by the mitochondria.
I am the coordinator of a precision medicine project at IMPACT, which has allowed me to be closer to the clinic and gain experience in coordinating a project involving both clinical and
basic research professionals. Additionally, I have served as an invited speaker at more than 70 national and international congresses. I have successfully supervised 9 theses, all of which received outstanding grades with honors, with some receiving awards of excellence. Currently, I am overseeing the direction of 3 theses. I have also supervised over 30 undergraduate or master's theses. I actively collaborate in mentoring young scientists. I have founded a association to promote science science to the kids specially to the girls. I have an organization that engage children in science and they go to schools and organize events to bring science to kids specially to girls. I was also a coordinator and tutor of the master's degree in biomedicine at the Autonomous University of Madrid.
She has received significant awards, including the L'Oréal-UNESCO Spain Award in 2010, the Prince of Girona ScienceAward in 2012, and the Estrella de Madrid in 2014. She was also honored by the Spanish Society of Biochemistry and Molecular Biology (SEBBM) in 2016 and was recently recognized as a Young EMBO Investigator in 2017. She received the AstraZeneca Young Investigator Award in 2018 and the Jesús Serra Award in 2018. In 2020, she was awarded the Young Investigator Award by the European Society for Clinical Investigation. In 2021, she received the Banco Sabadell Award and the Antoni Esteve Award. In 2022, she was honored with the Medals of Extremadura and the Province of Badajoz, as well as the Young Investigator Award from the University of Alcalá. In 2023, she received the Carmen and Severo Ochoa Molecular Biology Award, the award for best scientific career "Juan Florencio Macías Núñez," and the FIIPERVA Foundation Chair in 2023. In 2024, she was appointed a member of the Royal Academy of Veterinary Medicine and received the ABC Health Award. ABC Salud
