Retinoids and carotenoids: synthesis, study of metabolic routes and therapeutic usefulness.
Bis-polyenic pyridinium salts formed by macular degeneration connected with aging.
Nuclear receptors of retinoic acids (RAR, RXR): design and synthesis of selective modulators.
Development of antivirals against SARS-CoV-2 with dihidroxicyclopentene skeletons.
Development of synthetic routes to polyenes and natural polyenic macrolactams using cross-coupling reactions catalysed with palladium.
Synthesis of epigenetic enzyme modulators (HDAC, Jmj-C HDM) based on natural products.
Computational analysis of reactions catalysed with transition metals and pericyclic polyenic processes.
Stereoselective synthesis of bioactive polyenes.
Structural determination of natural products.
Separation and purification of bioactive products.