Retinoids and carotenoids: synthesis, study of metabolic routes and therapeutic usefulness.
Bis-polyenic pyridinium salts formed by macular degeneration connected with aging.
Nuclear receptors of retinoic acids (RAR, RXR): design and synthesis of selective modulators.
Development of antivirals against SARS-CoV-2 with dihidroxicyclopentene skeletons.
Development of synthetic routes to natural polyenes and polyene macrolactams using palladium-catalyzed cross-coupling reactions.
Synthesis of epigenetic enzyme modulators (HDAC, Jmj-C HDM) based on natural products.
Computational analysis of reactions catalysed with transition metals and pericyclic polyenic processes.
Stereoselective synthesis of bioactive polyenes.
Structural determination of natural products.
Separation and purification of bioactive products.
Synthesis of natural and synthetic copolymer hybrids (graft and block copolymers).Self-assembly of graft and block copolymers into solution-organized and surface-organized nanostructures.
Structural characterization of polysaccharides (nuclear magnetic resonance and gel permeation chromatography).
