Eventos
O xoves 18 de decembro ás 16:00 horas, Paula Mora Ayuso, do grupo ORCHID do CINBIO, defenderá a súa tese de doutoramento baixo o título “Síntesis del ácido nahuoico A y análogos estructurales como inhibidores de la metiltransferasa de histonas SETD8".
Será no Salón de Graos da Facultade de Ciencias Xurídicas e do Traballo, no campus de Vigo.
ABSTRACT:
In this thesis, the total synthesis of nahuoic acid A is presented, together with a series of analogues and the progress made toward the synthesis of another member of this natural product family, nahuoic acid Cii. Nahuoic acid A is of significant biological interest, as it is the first known cofactor-competitive inhibitor of the epigenetic lysine methyltransferase SETD8. Its synthesis is inspired by the hypothetical biogenesis of the octahydronaphthalene core, achieved through an intramolecular Diels–Alder (IMDA) reaction of an appropriate pentaenoate precursor.
BIO:
Paula Mora graduated in chemistry from the University Complutense of Madrid (Spain) and conducted her Master’s studies at the University of Birmingham (UK). In 2018 she started her PhD studies at the University of Vigo (Spain) under the supervision of Prof. Ángel R. de Lera and Prof. Rosana Álvarez. Her doctoral research is focused on the total synthesis of natural products as novel epigenetic modulators based on a bioinspired synthetic route.
